Crayo Precipitate

Definition: A component containing the crayoglobulin fraction of the plasma prepared from Fresh Frozen Plasma.

Properties: Its contents are the major portion of the Factor VIII, von Willebrand factor, fibrinogen, Factor XIII and fibronectin present in freshly drawn and separated plasma.

Methods of preparation: Since the freezing point of crayo is slightly higher then the remaining plasma, Fresh Frozen plasma is slowly thawed at +2 degrees Celsius to +6 degrees Celsius. The crayo depleted plasma is either extracted immediately during thawing with a siphon method, or if thawing was left overnight a hard spin is necessary before crayo depleted plasma is separated from the crayo precipitate. In any case, crayo is left as the unmelted (frozen) part in the original FFP bag. Obviously re-labeling is necessary.

Storage & Stability: The stability on storage is dependent on the storage temperature. Optimal storage temperature is at -25 degrees Celsius or lower. CP could be stored 12 months at temperatures below -30 degrees Celsius.